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The main takeaway from the article: Brady plans every detail of his life so he can play football as long as possible, and he'll do anything he can to get an edge. He diets all year round, takes scheduled naps in the offseason, never misses a workout, eats what his teammates call "birdseed," and does cognitive exercises to keep his brain sharp. Brady struggles to unwind after games and practices. He's still processing, thinking about what's next.

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Articles Citada per Coautors. The Quarterly Journal of Economics 3 , , Educational Evaluation and Policy Analysis 31 1 , , New directions for community colleges , , Journal of development Economics 87 1 , , Review of Economics and Statistics 92 3 , , Educational Evaluation and Policy Analysis 40 1 , , Journal of Economic Perspectives 23 4 , , Ajuda Privadesa Condicions.

Do community colleges provide a viable pathway to a baccalaureate degree? Do faculty serve as role models? Remediation at the community college: Student participation and outcomes EP Bettinger, BT Long New directions for community colleges , , How have college decisions changed over time? An application of the conditional logistic choice model BT Long Journal of econometrics , , Does female schooling reduce fertility? Looking beyond enrollment: The causal effect of need-based grants on college access, persistence, and graduation BL Castleman, BT Long Journal of Labor Economics 34 4 , , The impact of assessment and accountability on teacher recruitment and retention: Are there unintended consequences?

Out-of-field teaching and student achievement: Evidence from 'Matched-Pairs' comparisons. Thomas Dee , Sarah Cohodes. Possession and discounting behavior. Technology and voter intent: Evidence from the California Recall Election. Thomas Dee , Brian A. Sean F. Reardon , Joseph P. Who leaves? Teacher attrition and student achievement. Patterns of Hispanic students' math skill proficiency in the early elementary grades.

Reardon , Claudia Galindo. Download Research summary Appendices. Early childhood and the achievement gap. Susanna Loeb , Daphna Bassok. Institutional responses to reduce inequalities in college outcomes: Remedial and developmental courses in Higher Education. Eric P. Bettinger , Bridget Long.


Cites duplicades. Cites combinades. Penja un fitxer PDF. PDF Restaura Suprimeix definitivament. Seguiu aquest autor. Articles nous d'aquest autor. Citacions noves d'aquest autor. Articles nous relacionats amb la recerca d'aquest autor. Brad Hershbein Economist, W. Harvard University. Economics of Education. Articles Citada per Coautors. The Quarterly Journal of Economics 3 , , Educational Evaluation and Policy Analysis 31 1 , , New directions for community colleges , , Journal of development Economics 87 1 , , Robert L.

Within the last three decades, foraging theory has established itself as a major-arguably the dominant-cornerstone for both archaeological and ethnographic hunter-gatherer research. Until now, however, no introductory treatment has presented the subject in a form that was quantitatively explicit and yet easy to follow.

Designed as an introduction to undergraduate and graduate students new to the subject, and as a refresher for professionals seeking to broaden their command, Hunter-Gatherer Foraging: Five Simple Models presents the five foraging models that lend themselves best to hunter-gatherer application: diet breadth, linear programming, front- versus back-loaded resources, technological investment, and field processing. Each chapter begins with a hypothetical hunter-gatherer problem and takes the reader through the steps needed to state such problems in quantitative form and solve them.

Exercises with answers at the end of each chapter reinforce key concepts and methodology. From the reviews. The style is informal, often humorous, and it will clearly work well in a classroom of advanced undergraduates or graduate students.

The flow and clarity of the discussions almost makes one forget that this is math that they're trying to master. Basgall in Journal of California and Great Basin Anthropology "This book is the first of its kind to provide a suite of tools applicable to many ethnographic and archaeological foraging problems. It is certainly required reading for any student of the discipline, and as it finds its way into the classroom and onto the desks of practitioners, it is sure to become a classic.

Codding in California Archaeology "[A]n excellent primer on a group of models that.


Labirint Ozon. Hunter-gatherer Foraging : Five Simple Models. Robert L. Within the last three decades, foraging theory has established itself as a major-arguably the dominant-cornerstone for both archaeological and ethnographic hunter-gatherer research. Until now, however, no introductory treatment has presented the subject in a form that was quantitatively explicit and yet easy to follow.

Designed as an introduction to undergraduate and graduate students new to the subject, and as a refresher for professionals seeking to broaden their command, Hunter-Gatherer Foraging: Five Simple Models presents the five foraging models that lend themselves best to hunter-gatherer application: diet breadth, linear programming, front- versus back-loaded resources, technological investment, and field processing.

Each chapter begins with a hypothetical hunter-gatherer problem and takes the reader through the steps needed to state such problems in quantitative form and solve them. Exercises with answers at the end of each chapter reinforce key concepts and methodology. From the reviews. The style is informal, often humorous, and it will clearly work well in a classroom of advanced undergraduates or graduate students. The flow and clarity of the discussions almost makes one forget that this is math that they're trying to master.

Basgall in Journal of California and Great Basin Anthropology "This book is the first of its kind to provide a suite of tools applicable to many ethnographic and archaeological foraging problems. He doesn't have enough passion for teaching. Does not put the effort to explain, and tests heavy.

In this course he graded me with a B, which I didn't deserve. But, what, in the following english classes such as Composition 1, I got an A. If you really want to learn and pass the class, better chose another instructor. Test heavy Tough grader. Jun 8th, Would Take Again: No. Tough Grader Skip class? You won't pass. Nov 26th, This professor is so bad, he doesn't teach well, he is also bad on grading.

Sep 25th, Aug 17th, Bettinger is an excellent professor. I enjoyed his class. Respected Clear grading criteria Caring. Sep 9th, Attendance: Mandatory. Poor teacher he does not care at all. He only talks about negative stuff every time. I do not recommend this Proff.

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Although the primary aim of the study was to identify the rate at which the BBB healed after BBBD, several peripheral results provided compelling support for the implementation of monodisperse microbubbles to improve control over treatment.

The results showed that BBB healing occurred in the reverse of permeabilization, starting at the outer edges of the treatment region and moving towards the center. Additionally, the time for BBB closing was dependent on microbubble size.

Previous studies had shown that the time of BBB closing was approximately h with polydisperse commercial formulations [ 53 ]. The authors explained this result as being a consequence of larger pores created by larger microbubbles. Additionally, tissue damage dark neurons, extravasated red blood cells seen initially with short time-course studies was not observed, or greatly mitigated in the mice, suggesting that disrupted tissue may recover after a few days.

Preliminary data by Song et al. While clinical microbubbles are expedient for rapidly moving the technology to clinical trials, many researchers believe that UCA compositions originally developed for diagnostic imaging are suboptimal for BBBD. However, very few studies have systematically investigated the effect of microbubble composition on the measures of BBBD.

Wu et al. Interestingly, increasing microbubble tail length resulted in a significant increase in kDa fluorescent dextran extravasation, while insignificant differences were seen for 3-kDa dextran. This suggests that microbubbles comprising longer acyl-chain lipids, which are known to circulate longer in vivo [ 58 ], may favorably affect delivery efficiency of larger drug molecules.

The composition of the gas core has been shown to dictate circulation persistence due to varying solubility and diffusivity [ 59 , 60 ], but few other bioeffects have been linked to gas composition. Microbubble complexes have been engineered for improved control over BBBD and subsequent drug delivery. Burke et al. Clearly, more research is warranted to optimize microbubble design and complexation for BBBD applications.

As we describe above, microbubble concentration and size distribution can be combined into a single dose parameter: the microbubble volume dose MVD. Both microbubble composition gas and shell and dose are expected to affect the pharmacokinetics circulation half-life and area-under-the-curve. Note that physiological e. The pressure amplitude is diminished by attenuation from the transducer, coupling agent, skin, skull and brain tissue beneath, as well as reflections at the boundaries between them.

The ratio by which the transmission is decreased can be estimated by the following equation [ 64 ]:. Where T is the overall pressure amplitude transmission coefficient; P 0 and P are the pressures transmitted by the transducer and into the brain, respectively; Z 1 , Z 2 and Z 3 are the acoustic impedances for skin [1. The cm transducer, driven at kHz and 0. BBBD was seen, however, with the size-isolated microbubbles, and in subsequent studies with Definity by McDannold et al. In the non-human primate study mentioned above [ 69 ], the results showed that BBBD was not visible at some acoustic intensities that induced inertial cavitation recorded with a passive cavitation detector.

Treatments at 0. A study by Sheikov et al. As opposed to vascular compromise, the primary means of marker transfer into the parenchyma was reported to be transcytosis at 0. Future studies will likely need to optimize not only FUS parameters, but also MB dose, when choosing a specific target in the brain for drug delivery. Microbubble dose at the target site is affected by a combination of microbubble dissolution and clearance in specific organs, namely the lungs, liver and spleen [ 52 , 72 ].

Some of these factors can be expediently controlled through microbubble parameters [ 58 ]. However, the partial pressures of dissolved gases in the blood, which are directly affected by inhaled gas composition and physiology of the cardiopulmonary circuit, have also been shown to control microbubble circulation persistence [ 45 , 50 ]. Additionally, it is known that decreasing pO 2 can trigger the formation of adenosine and other potent vasodilators, increasing cerebral blood flow and likely the concentration of microbubbles at the target site [ 73 ].

Results by McDannold et al. In rats, for example, the resting heart rate is bpm [ 75 ], while the resting heart rate in humans falls within bpm, which may significantly alter the availability and clearance of microbubbles before and during BBBD. Before the incorporation of microbubbles, ultrasound parameters were among the first to be examined in the context of BBBD.

Although this new method was non-invasive and could spatially target treatment regions deep within the body, the resulting cell death and tissue damage limited translatability. It was almost 55 years before the first exogenous microbubble-assisted permeabilization of the BBB was conducted by Hynynen et al. These early microbubble studies demonstrated that BBBD could be achieved with much lower acoustic amplitudes than with ultrasound alone, greatly reducing the risk of neuronal and parenchymal tissue damage [ 24 , 78 , 79 ], and enabling a greater variety of effects beyond local heating.

Although these early studies examined the effect of varying ultrasound parameters, it is important to consider the significant interaction between acoustic, microbubble and physiological parameters as outlined below. While several studies indirectly examined mechanical index by varying acoustic pressure or frequency alone, few studies have examined the effect of mechanical index by varying both pressure and frequency.

Experimental results from Chu et al. Early in vitro studies of microbubbles demonstrated that inertial cavitation occurs at MI as low as 0. An MI of 0. For example, increasing the number of ultrasound cycles at a fixed MI has been shown to significantly increase BBBD [ 69 ], and significant immune response has been observed at MI under 0.

In addition to affecting mechanical index, the pulse center frequency affects cranial attenuation. While in vitro studies with macaque attenuation: 4. Microbubble resonance frequency has been reviewed by Doinikov et al. The linearized resonance frequency f 0 for small-amplitude oscillations of lipid-shelled microbubbles is given by [ 87 ]:. The nonlinear acoustic behaviors of forced bubble oscillation are dependent on the mismatch between the microbubble resonance frequency and the driving frequency, the acoustic pressure and microbubble distribution in the insonified area.

Therefore, isolating the effects of frequency necessitates the use of monodisperse microbubbles at matched mechanical index and MVD. Such a study has yet to be reported in the literature. The acoustic attenuation differs between animal models, but clear trends exist between increasing acoustic pressure and its bioeffects, although the effects of varying PNP alone, independent of MI , are unclear. It is generally well-established that increasing acoustic pressure increases the relative expansion and wall velocities of microbubbles, and is thus linked to increased BBBD as well as BBBD-related effects such as petechiae formation [ 24 , 78 , 88 , 17 ].

An acoustic output-control scheme currently used in at least one clinical trial is the feedback-facilitated adjustment of PNP to induce stable-cavitation-mediated BBBD [ 16 , 18 ]. This approach was demonstrated by O'Reilly et al. This method revealed that peak pressures as low as 0. This type of feedback control is currently in use in clinical trials.

In comparison with mechanical index and frequency, the effects of pulse repetition frequency PRF and pulse length have received less attention. In general, a simultaneous increase in PRF and pulse length N number of cycles per pulse; T time per pulse is expected to increase BBBD by increasing duty cycle [ 89 ]:. Contrary to early results obtained by McDannold et al. While increasing pulse length has been shown to improve model drug penetration into the parenchyma [ 82 ], it has also been hypothesized that long pulse lengths increase the occurrence of standing waves, inducing off-target effects and increasing tissue damage [ 13 , 89 ].

BBBD safety has been a long-standing concern related to the standardization of ultrasonic and microbubble parameters. Qualitative assessments of excised neural tissue evidence of dead or compromised parenchyma and quantitative assessments of behavior motor function after recovery period have been the most common means of evaluating BBBD safety [ 70 , 89 , 90 ].

In contrast, the safety of potential pharmaceutical agents is often comprehensively evaluated with quantitative immunostaining, high-throughput imaging and relevant functional tests; for motor function, studies often included rotarod performance, grip-strength tests and behavioral assays such as the Basso-Beattie-Bresnahan locomotor rating scale for rats, and Basso Mouse Scale for mice. Some studies have observed the presence of petechiae, or visually detectable extravasated red blood cells [ 90 , 88 , 13 , 74 ].

Contradictory interpretations regarding the impact of petechiae on safety have been presented. Another early mode of examination of BBBD safety was qualitative observations of hemorrhage and edema as indicated by MRI imagery [ 24 ].

While several MRIg-FUS studies have suggested that such results demonstrate effective BBBD with minimal or no hemorrhaging, low level of hemorrhaging has not been conclusively evaluated. Indeed, the effect of just heme and other erythrocyte components is poorly understood [ 91 ].

However, it makes sense that in the case of BBBD, micropetechiae are a byproduct of transiently compromising cerebral vasculature to induce macromolecular delivery. It is important to emphasize that the presence of petechiae may not be evidence of trauma post-BBBD. Although petechiae are often present in cases of brain jury, sufficient BBBD for passage of drugs and biomolecules may be accompanied by extravasation of red blood cells. A complementary means of evaluating neuronal insult is immunostaining for activated immune cells, specifically, microglia.

Microglia are the primary immune cells in the brain and are critical for monitoring the brain for pathogens and foreign molecules, as well as responding to injury. Activation of microglia is readily detected using antibodies to cell markers, such as anti-Iba1 Figure 6.

Unlike qualitative assessments of neuronal health, studies of immune cells have demonstrated significant immune cell response to BBBD [ 50 ]. A handful of studies have examined cellular stress in this manner [ 45 , 50 ]. In , Kovacs et al. Activated astrocytes and microglia were still present six days after the study. On the other hand, McMahon et al. Behavioral studies are another fundamental component in the study of therapeutic neurologic agents, ranging from fine motor control tests to behavioral scoring.

Studies on macaques indicated that two minutes of FUS applied at 0. However, animal cognitive performance was reported to return to baseline four days after sonication [ 90 ]. A similar study was conducted by Olumolade et al. While functional deficits were observed immediately after BBBD for the positive control group, no significant differences in rotarod or open field tests were observed after four weeks at 0.

Today, at least monoclonal antibodies are approved for clinical use as listed in the FDA-approved list of biologics. In addition to potential therapeutic effects, such antibodies can also be used for diagnosis when bound to MBs or other reporters.

By coupling the specificity of antibodies with BBBD, targeted theranostics represent a non-invasive means of cost-effectively diagnosing and treating pathologies beyond the BBB. Conventional diagnosis of AD begins with an implicative approach, by way of behavioral symptoms and family history, and no physiological test short of a post-mortem biopsy is able to identify positively AD pathologies.

In , Raymond et al. Doxorubicin, co-injected microbubbles were stimulated in GL brain tumors with Similarly, Yang et al. Neither studies reported the presence of tissue damage after histological staining. Burgess et al. On the other hand, modified viral particles have been shown to induce robust transduction in neurons, and at least six studies have demonstrated successful transduction of neurons using adeno-associated virus AAV [ - , 14 ].

Numerous studies have been published on the effect of acoustic parameters, oftentimes highlighting the feasibility of novel methodological and analytical techniques; fewer studies have isolated the effect of the microbubbles themselves, and even fewer have focused on biochemical, immunological and physiological parameters. Challenging this goal are the numerous permutations of microbubble, ultrasound and physiological parameters. Specifically, readily varied parameters such as FUS frequency and amplitude have been extensively studied, but the lack of optimized and commonly shared parameters in microbubble formulations, dosage metrics, animal models, as well as histological and behavior assays for safety have stymied productive overlap in past studies.

While unified parameters, such as mechanical index MI and microbubble volume dose MVD , incorporate multiple individual parameters into single reference parameters that may be more suitable for standardization, optimization of such parameters and others, as well as deeper characterization of their tissue- and cell-level effects, remain yet to be completed.

World Health Organization, editor. Neurological disorders: public health challenges. Geneva: World Health Organization. Front Public Health [Internet]. Scheld WM. Drug delivery to the central nervous system: general principles and relevance to therapy for infections of the central nervous system.

Rev Infect Dis. Little RC. Physiology of the heart and circulation. Chicago: Year Book Medical Publishers. Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci. Deeken JF, Loscher W. Clin Cancer Res. Boron neutron capture therapy of brain tumors: enhanced survival following intracarotid injection of either sodium borocaptate or boronophenylalanine with or without blood-brain barrier disruption.

Cancer Res. Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier. Methods Enzymol. Brechbiel MW, editor. MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits. Ultrasound Med Biol. Microbubble gas volume: A unifying dose parameter in blood-brain barrier opening by focused ultrasound. Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging. Proc Natl Acad Sci.

Feedback control of microbubble cavitation for ultrasound-mediated blood-brain barrier disruption in non-human primates under magnetic resonance guidance. J Cereb Blood Flow Metab. Ellegala DB. Curr Pharm Biotechnol. MR temperature mapping of focused ultrasound surgery. Magn Reson Med. Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Zhou Y. Correlation between inertial cavitation dose and endothelial cell damage in vivo.

Johnsen E, Warnez M. Tissue damage produced by cavitation: The role of viscoelasticity. J Acoust Soc Am. Biophys J. Blood vessel rupture by cavitation. Urol Res. Observations of translation and jetting of ultrasound-activated microbubbles in mesenteric microvessels. Preliminary observations on the spatial correlation between short-burst microbubble oscillations and vascular bioeffects.

The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in mice. Chen H, Konofagou EE. The size of blood-brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure. Toborek M, editor. Sci Rep [Internet]. The blood-brain barrier: an engineering perspective. Front Neuroengineering [Internet]. Mol Pharm. J Neurophysiol. Brain delivery of microencapsulated GDNF induces functional and structural recovery in parkinsonian monkeys.

Disrupting the blood-brain barrier with focused ultrasound: Perspectives on inflammation and regeneration. Reply to Silburt et al. McMahon D, Hynynen K. Focused ultrasound with microbubbles induces sterile inflammatory response proportional to the blood brain barrier opening: Attention to experimental conditions. Sci Rep. Ultrasound enhancement of liposome-mediated cell transfection is caused by cavitation effects. Sonoporation of cultured cells in the rotating tube exposure system.

Disrupting the blood-brain barrier by focused ultrasound induces sterile inflammation. Effect of microbubble size on fundamental mode high frequency ultrasound imaging in mice. Iedereen zal dit beamen, een collega voor het leven, voor altijd! Dankjewel Vanessa, voor alles Je collegaatjes van de crisisunit xxx. Meiden van de brandweer Lieve Nessa, het begon allemaal 4 jaar geleden met 'Meiden van de brandweer', het filmpje dat je samen met enkele vriendinnen maakte voor ons huwelijk.

We kenden elkaar nog niet zo goed, maar al snel leerde ik je kennen als een spontane, warme meid die altijd te vinden was voor een feestje, en absoluut een sfeermaker was! Bedankt voor deze prachtige herinnering aan jou, Kristof en ik zullen deze zeker koesteren. Dikke zoen, Katrien. Lieve Vanessa toch Zo blij dat we elkaar de afgelopen maanden nog toevallig tegen zijn gekomen buiten het werk.. Ik wens de familie en vrienden veel sterkte, moed en kracht om dit oneerlijke verlies te dragen.

Totaal overrompeld beleefden we van op afstand het tragische gebeuren. We wensen de familie - als buren van Vanessa - veel sterkte toe in de komende dagen. We hopen dat doorheen het krachtige verdriet er plaats is voor de vele mooie herinneringen aan haar. Laat haar stem, haar wijze van zijn voortleven in jullie hart en jullie leiden doorheen het verdere leven.

Broeder, Je hoeft niet sterk te zijn, laat je gevoelens hun vrije loop gaan en geniet van de mooie herinneringen.. Dat aan haar denken een lach op jullie gezichten tovert zou haar goed doen. Nessa, Jij hebt mij in der tijd door de moeilijkste periode in men leven geholpen je was er altijd voor mij en ik zal uw lach en zotte kuren nooit vergeten. Door omstandigheden zijn we elkaar jaren uit het oog verloren maar sinds dit jaar hadden we terug contact en we zouden afspreken maar dat is er jammerlijk Ni van gekomen.

Nessa ik ga u nooit vergeten en ge zult voor mij altijd mijn BFF zijn. Ga u missen. Lieve Monique en familie, Wij zouden graag onze innige deelneming betuigen bij dit immense verdriet. Wij hopen dat dierbare herinneringen aan mooie momenten enige troost kunnen bieden.

Wij wensen u en uw familie heel veel sterkte toe. Liesbet en Manu Ysewyn-Heremans. Lieve Monique en Francis, heel veel sterkte gewenst, wat in jullie hart zit zal nooit verdwijnen Dikke knuffels Ed en Anne. Een collega uit de ! Voor eender welke klus of gekke activiteit op het werk.. Er was er altijd 1 die zich kandidaat stelde! Zoveel herinneringen die we nooit zullen vergeten! Wij zullen jouw manier van werken trachten verder te zetten, daar kan je op rekenen! X Joyce.

Mijn deelneming voor dit grote verlies! Ik herinner me alleen maar goede dingen met Vanessa zoveel jaar geleden dag in dag uit op school naast school ,ik kwam zo graag bij je gezellige thuis! Ik vind geen woorden om mijn steun te betuigen , veel sterkte aan de familie.

Je vond dit geweldig en ons bezoekje op uw camping zal ons eeuwig bij blijven. Ik vond dit als peter van u zeer normaal. We gaan volgend jaar een leeg plaatsje hebben in onze koffer maar wees gerust dat je een enorme ruimte hebt ingenomen in ieders hartje van onze familie. We gaan je enorm missen Nessa, dikke knuf van uw peter, Joke en al onze kids.

Innige deelneming , Dirk en Jeannine Marien Janssens. Veel sterkte aan de ganse familie. Super Nes for ever! Liefste Nessa, Het blijft niet te vatten, zo onwerkelijk! Zo jammer dat ik je een jaar of 6 uit het oog verloren ben, al een geluk hebben we het afgelopen jaar terug contact gehad, daarmee prijs ik me gelukkig. Je bent en blijft een topper!!! Die lach die er altijd was, die vergeet ik nooit! Ik wil je echt voor alles bedanken!!!

We gaan je nooit vergeten! Tom, ann, jolien en leni Xxx. Francis en Monique, Wij nemen innig deel in het leed dat jullie treft bij het heengaan van Vanessa. Heel veel sterkte in deze moeilijke dagen. John en Rita Faes - Hermans. Bedankt voor je vriendschap. Bedankt voor alle topmomenten. Bedankt voor je fantastische lach. Ik ga je onnoemelijk hard missen en vergeten doe ik je nooit. Dikke kus. Sol, tapas y amistad!

Valencia, baby! Wat een tijd! Even weg van alles, aan niets moeten denken. De enige problemen die we moesten oplossen waren: waar gaan we tapas eten? Drinken we cava of sangria? En hoeveel bollen ijs nemen we? Dit moesten we en zouden we vaker doen. Ik beloof je dan ook overal mee naartoe te nemen, elke plek waar ik kom, ben jij ook. Klaar om de wereld te zien?! Sterkte aan heel de familie Na vele jaren zijn we elkaar uit het oog verloren. Nu recent hadden we weer contact en zag ik er naar uit om m'n nicht terug te leren kennen.

Het is een tragedie om je nu al te verliezen en ik weet geen woorden die voldoende troost zullen bieden. Maar ik koester de herinneringen die ik heb en neem het voor eeuwig mee in m'n hart. Sterkte Tom, Nonkel cisse en tante Nikki en aan heel de familie. Groetjes sharis. Heel veel sterkte!! Het mooiste huwelijkscadeau ooit Lieve Nessa, Wat een prachtige huwelijkscadeau kregen we van jou. Samen met m'n andere lieve vriendinnen maakte je dit geweldige filmpje.

Ik ben zo blij met deze mooie herinnering aan jou. Als ik dit filmpje bekijk verschijnt er spontaan een grote glimlach op m'n gezicht want dan zie ik jou. Dit toont perfect hoe je was: vrolijk, vol energie, een echte sfeermaker. Wat waren de feestjes met jou altijd fijn! Je stond altijd klaar vol enthousiasme om er samen met ons iets leuk van te maken.

Bedankt voor al deze fijne momenten! Je bent een topper! Sterkte in deze moeilijke dagen , maar weet dat ze altijd aanwezig zal zijn in jullie huis en harten. Liefs van Charles en Nancy. Veel sterkte aan familie EN vrienden van nicole en theo.

Veel sterkte aan de familie vanwege Daisy en Gino. Onze oprechte deelneming in dit onrechtvaardige verlies. Veel sterkte Tom, Een broer of zus verliezen is onwezenlijk, onecht, hard. Ik heb het zelf meegemaakt en weet waar jij nu doorgaat. Heel veel sterkte en moed voor jou en je ganse omgeving. Met oprechte deelneming!!!!!!! Onze oprechte deelneming Tom Ellen en de ganse familie vanwege Leo en Ingrid. Veel sterkte aan de ganse familie Van Sven en Diane.

Francis,Monique, Tom, Ik denk nu terug aan heel lang geleden, wij waren nog kleine kinderen Hoe oud was ik? Steve Mast. Een geweldige en-meer uren. Heel de nacht lang beverbende spelen, tetteren, lachen, gieren, koud krijgen, zo dicht mogelijk bij een gasvuur kruipen of een vossenpak aantrekken, wandelen, lopen, cavatjes drinken en als 's morgens de zon erdoor komt, cava-ontbijt!

Het was een weekend vol emoties, super intens. Iedereen doodop op zondagnamiddag en dan kan het al eens moeilijk zijn om de weg te vinden in het Fort. Je was je auto gaan zoeken, maar kwam zonder auto en in tranen terug. Geen succes.

We moesten er geweldig om lachen en jijzelf ook. Dit jaar vormen we 1 team met z'n allen, en we gaan er opnieuw volledig voor, maar wat gaan we jou missen Vanessa!! Zo'n enthousiaste, zotte en goedlachse verschijning zie je niet vaak, wauw! Dikke knuffel x. Schonenberg-Hendrikx Brasschaat. Er zijn geen woorden voor Lieve Monique en Francis, Tom en Ellen, Als dit een troost mag zijn, jullie leren ons: "Ervaring is niet wat een mens overkomt. Het is wat een mens doet met wat hem overkomt.

Paul, Bieke en kinderen. Heel veel sterkte aan gans de familie! Sandy,Dimi,Lune en Lily. Heel veel sterkte voor iedereen. Veel sterkte aan Tom, Ellen, Monique,Francis en heel de familie. Onze gedachten zijn bij jullie.

Veel sterkte. Veel sterkte voor de familie! Innige deelneming, veel sterkte aan de hele familie Michelle Nicole Moerbeek. Heel veel sterkte voor de familie!! One Direction-fans forever! We zijn er trots op en steken het niet onder stoelen of banken.. Wij noemen die jongens zelfs "onze vrienden"! In de auto, op de fiets, op het werk of onder de douche: de vrienden zijn altijd van de partij!

Voortaan kweel ik dubbel zo hard mee, daar kan je op rekenen! Sterkte voor de hele familie. Ik kende je niet persoonlijk maar als ik zie hoe een toffe broer en schoonzus je had kan ik alleen maar weten dat ook jij een prachtig persoon moet geweest zijn Heel veel sterkte aan gans de familie, vrienden Heel veel sterkte voor jullie allemaal. Sterkte met jullie grote verdriet. Groet, Frieda en Frank van der Oest - Verbeke.

Veel sterkte! Die dag Die dag, Jouw ogen gingen toe, Die dag was iedereen plots heel moe. Overweldigd door immens verdriet Onrealistisch, veel ongeloof Want dit kan toch helemaal niet. Laat je niet wijsmaken dat je sterk moet zijn Maar maak plaats voor veel verdriet en al jouw pijn.

Wanneer de woorden je overvallen, 'Veel sterkte beste vriend', Mag je het lezen als: Jouw zus was zo mooi, zo puur En echt bemind. Er komt een dag zonder tranen of verdriet Er komt een dag dat je enkel terug haar glimlach ziet. Die dag, Een herinnering aan elk fragment, van jullie samen, als broer en zus, dat mooie moment!

Lieve Tom en Ellen, Lieve papa en mama, Lieve familie, Zoek veel steun bij elkaar in deze moeilijke tijd. Heel veel sterkte in deze moeilijke tijd. Laat vele fijne herinneringen het verdriet verzachten. Veel sterkte aan de naaste familie. Heel veel sterkte, vanwege Danny,Tania, Sam en Vincent. Veel sterkte aan gans de familie.

Lieve tom, ellen en hele familie Wij willen jullie veel sterkte wensen met het verlies van jullie zus, schoonzus,dochter, mama, Veel sterkte voor familie en vrienden in deze moeilijke tijden. Een fyne Chiro meid Het ga je goed Vanessa.

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