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The main takeaway from the article: Brady plans every detail of his life so he can play football as long as possible, and he'll do anything he can to get an edge. He diets all year round, takes scheduled naps in the offseason, never misses a workout, eats what his teammates call "birdseed," and does cognitive exercises to keep his brain sharp. Brady struggles to unwind after games and practices. He's still processing, thinking about what's next.

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These components are prepared into a genetic circuit by which extracellular heme is transported into the cell to activate the photoluminescent output in a dose-dependent manner with adequate signal-to-noise ratios. Engineered E. Optical signatures from engineered bacterial sensors are detected using phototransistors interfaced with an on-board low-power luminometer.

The optical signal is quantified, digitized, and then wirelessly transmitted using electronics and an antenna on a device that is powered by a 5 mAh battery. The integrated system was reported to be stable in gastric fluid for up to 36 h while the low-power electronics permit operational device lifetimes of up to 6 weeks.

Devices loaded with heme-detecting E. This study is compelling because of the intrinsic modularity of the genetically engineered bacterial sensors. Variants of E. Decoupling the sensing element from the electronics is convenient from both a technology and regulatory perspective. Benign endogenous bacteria with engineered genetic circuits could, in principle, be designed and optimized to detect virtually any small molecule or protein including specific biomarkers for measuring metabolism, detecting GI pathologies, or profiling microbiome composition.

Furthermore, it may be possible to multiplex various bacterial sensors on to one ingestible device to measure panels of molecules simultaneously. These data may provide insight into gut health from various perspectives. Decoupling the sensing element from the electronic components can expedite the regulatory approval of these devices as diagnostics for many disease states. Once the initial device is approved in humans, this technology could serve as a predicate device for subsequent technologies using the k regulatory pathway.

As such, the era of innovations in genetic engineering has now interfaced with endoradiosonde. In the near future, it may be possible to engineer bacterial sensors to measure the concentrate of small molecule metabolites or other markers for metabolic disease or gut health. Early diagnosis may improve the ability to intervene, treat, and manage these diseases.

Microbial-electronic sensors could also be potentially integrated with on-board therapeutic interventions such as drug delivery reservoirs. The present device uses custom electronic circuits designed and fabricated using off-the-shelf components such as batteries, printed circuit boards, and encapsulation materials.

The materials selection process for device components is often motivated by convenience. However, the lack of application-specific materials can subject prospective patients to significant risk associated with device retention or acute toxicity. Next-generation edible electronics may benefit from novel components such as biocompatible batteries, flexible electronics, and biodegradable encapsulation materials 7 - 9.

Edible electronic devices that use flexible, degradable, and biocompatible materials may reduce risk, expedite regulatory approval, and accelerate adoption. Combining advances in synthetic biology with those in biocompatible, biodegradable, and flexible electronics could create a new era in the design of edible electronic devices to diagnose and treat many diseases in the gut and beyond. Figure 1 Early demonstrations of edible devices to detect bleeding. A This device includes a circuit that contains a sodium perborate window in close proximity to a thermistor.

B In the presence of blood, an exothermic chemical reaction is transduced into a thermal signature that can be relayed to an external receiver. Reprinted by permission from Springer Nature. Kimoto et al. Copyright Figure 2 Edible sensors for bleeding detection that integrate engineered microbial sensing elements. A Devices house E.

C,D This optical signature is quantified by an on-board low-power luminometer that then transmits the data to an external receiver. This device can detect bleeding in porcine subjects in less than 2 h after deployment. E The modular nature of the device can also detect the presence of other biomolecules that may be important for gut health. From Mimee et al. Reprinted with permission from AAAS.

It provides quantitative understanding of the mechanical behavior of molecules, cells, tissues, organs, and whole organisms. The field has seen a wide range of applications from the optimization of tissue regeneration to the design of surgical and rehabilitation devices. Both provide the necessary foundation in the underlying physical principles and their non-Biomedical Engineering applications. Education in biomechanics enables students to pursue careers in medical devices or rehabilitation engineering.

In addition to the Biomedical Engineering core courses, students in the BMEC Track must take must take the following combination of three courses:. Some Special Topics, newly offered or intermittently offered courses may be acceptable as track electives. Students should consult with their advisors and petition the BME Undergraduate Affairs Committee for permission to include such courses as track electives.

This track prepares students for careers in medical imaging or smart prosthetics. In addition to the Biomedical Engineering core courses, students in the BSIP Track must take the following combination of three courses:. The CMBT track emphasizes fundamentals and applications of biochemistry, biophysics, and cell biology, and processes on the nanometer to micrometer size scale. Students in this track acquire understanding of the molecular and cellular bases of life processes, and build skills in quantitative modeling of live cell-based biotechnologies and in technologies that exploit the unique properties of biomolecules in non-biological settings.

The CMBT track is ideally suited for the combined education of Biomedical Engineering and Chemical Engineering, which provides a strong core of chemistry and molecular processing principles. Students are allowed to design the "track" portion of the curriculum in consultation with the faculty. Example themes include medical robotics, neural engineering, or computational biomedical engineering. In addition to the Biomedical Engineering core requirements, students must take three elective courses of at least 9 units each.

These elective courses must form a coherent theme that is relevant to biomedical engineering. In addition, at least one of the elective courses must be judged by the Biomedical Engineering Undergraduate Affairs Committee to have substantial biological or medical content. Professor Conrad M. The minor program is designed for engineering students who desire exposure to biomedical engineering but may not have the time to pursue the Biomedical Engineering additional major.

The program is also open to students of all colleges and is popular among science majors. In conjunction with other relevant courses, the program may provide a sufficient background for jobs or graduate studies in biomedical engineering. Students interested in a medical career may also find this program helpful. The Biomedical Engineering minor curriculum is comprised of three core courses and three electives.

Some Special Topics, newly offered or intermittently offered xxx may be acceptable as electives. Students should consult with their advisors and petition the Biomedical Engineering Undergraduate Affairs Committee for permission to include such courses.

Priority for enrollment in or will be given to students who have declared the Additional Major in Biomedical Engineering. If sufficient room in the course remains after all majors have been accommodated in a given semester, students who have declared the Biomedical Engineering Designated Minor will be given the next priority for enrollment. If space still allows, other students will be enrolled. Each Carnegie Mellon course number begins with a two-digit prefix which designates the department offering the course xxx courses are offered by the Department of English, etc.

Although each department maintains its own course numbering practices, typically the first digit after the prefix indicates the class level: xx-1xx courses are freshmen-level, xx-2xx courses are sophomore level, etc. Please consult the Schedule of Classes each semester for course offerings and for any necessary pre-requisites or co-requisites. D, Carnegie Mellon University, ;. Department of Biomedical Engineering. Common Requirements for the Additional Major The Biomedical Engineering additional major program takes advantage of curricular overlaps between Biomedical Engineering and traditional engineering majors, such that the dual major can be completed in four years with only a modest increase in course requirements.

Requirements Minimum units required for minor: 57 Modern Biology 9 Introduction to Biomedical Engineering co-req. See the online catalog for a listing of courses. Any xxx course with a or higher number and worth at least 9 units. The course has a limited capacity and priority is given to students who have declared the Additional Major in Biomedical Engineering.

The project must be supervised by a core or courtesy Biomedical Engineering faculty member and for 9 or more units. Course Descriptions Note on Course Numbers Each Carnegie Mellon course number begins with a two-digit prefix which designates the department offering the course xxx courses are offered by the Department of English, etc. The course will focus on four areas: biotechnology, biomechanics, biomaterials and tissue engineering and biosignal and image processing and will introduce the basic life sciences and engineering concepts associated with these topics.

Pre-requisite OR co-requisite: Modern Biology. Arrangements may also be made via the Associate Head of BME for off-campus projects provided that a regular or adjunct BME faculty member agrees to serve as a co-advisor. The nature of the project, the number of units, and the criteria for grading are to be determined between the student and the research advisor.

The agreement should be summarized in a two-page project description with sign-off by the research advisor and a copy submitted for review and filing with the BME Department. A final written report of the results is required. Units may vary from 9 to 12 according to the expected time commitment, with one unit corresponding to 1 hour of research per week.

One but not more than one semester of research, if registered for at least 9 units, may be counted as a restricted elective course toward the BME additional major. It provides an overview of professional topics including bioethics, regulatory issues, communication skills, teamwork, and other contemporary issues.

Outside speakers and case studies will describe real world problems and professional issues in biotechnology and bioengineering, and progress toward their solution. Prerequisite or co-requisite: Introduction to Biomedical Engineering Physiology Fall and Spring: 9 units This course is an introduction to human physiology and includes units on all major organ systems.

Particular emphasis is given to the musculoskeletal, cardiovascular, respiratory, digestive, excretory, and endocrine systems. Modules on molecular physiology tissue engineering and physiological modeling are also included. Due to the close interrelationship between structure and function in biological systems, each functional topic will be introduced through a brief exploration of anatomical structure.

Basic physical laws and principles will be explored as they relate to physiologic function. Prerequisite or co-requisite: Modern Biology, or permission of instructor. The experimental modules reinforce concepts from Introduction to Biomedical Engineering and expose students to four areas of biomedical engineering: biomedical signal and image processing, biomaterials, biomechanics, and cellular and molecular biotechnology.

Several cross-cutting modules are included as well. The course includes weekly lectures to complement the experimental component. Pre-med students should register for Priority for enrollment will be given to students who have declared the Additional Major in Biomedical Engineering. Models considered will be drawn from a broad range of applications and will be based on algebraic equations, ordinary differential equations and partial differential equations.

The tools of advanced engineering mathematics comprising analytical, computational and statistical approaches will be introduced and used for model manipulation. Prerequisites: or or and or Introduction to Biomechanics Fall: 9 units This course covers the application of solid and fluid mechanics to living tissues. This includes the mechanical properties and behavior of individual cells, the heart, blood vessels, the lungs, bone, muscle and connective tissues as well as methods for the analysis of human motion.

Students will learn to identify product needs, how to specify problem definitions and to use project management tools. Methods to develop creativity in design will be introduced. The course sequence is comprised of two parts: is offered in the Fall semester and provides the students the opportunity to form project teams, select and define a project, create a development plan, and complete an initial prototype.

This course culminates in the completion of multiple prototypes, a poster presentation, and a written report. Prerequisite: Senior standing in Biomedical Engineering. Co-requisite: Prerequisite: BME Design Project Spring: 9 units This course sequence introduces Biomedical Engineering students to the design of useful biomedical products to meet a specific medical need. Prerequisite: Engineering Biomaterials Fall: 9 units This course will cover structure-processing-property relationships in biomaterials for use in medicine.

This course will focus on a variety of materials including natural biopolymers, synthetic polymers, and soft materials with additional treatment of metals and ceramics. Topics include considerations in molecular design of biomaterials, understanding cellular aspects of tissue-biomaterials interactions, and the application of bulk and surface properties in the design of medical devices.

This course will discuss practical applications of these materials in drug delivery, tissue engineering, biosensors, and other biomedical technologies. Open only to juniors or seniors in CIT, or by permission of instructor. Prerequisites: or or Biosensors and BioMEMS Intermittent: 9 units This course emphasizes the principles of biomolecule-based sensing, including molecular recognition, biomolecular binding kinetics and equilibrium; methods of detection and signal transduction, including optical, colorimetric, fluorescence, potentiometric, and gravimetric techniques; statistical principles of high throughout screening; microfluidic and microarray device design principles and fabrication technologies; molecular motors.

Prerequisites: OR Biochemistry. Prerequisite: Introduction to Biomedical Imaging and Image Analysis Fall: 12 units This course gives an overview of tools and tasks in various biological and biomedical imaging modalities, such as microscopy, magnetic resonance imaging, x-ray computed tomography, ultrasound and others. Students will be exposed to the major underlying principles in modern imaging systems as well as state of the art methods for processing biomedical images such as deconvolution, registration, segmentation, pattern recognition, etc.

The discussion of these topics will draw on approaches from many fields, including physics, statistics, signal processing, and machine learning. As part of the course, students will be expected to complete an independent project. Students will have the opportunity to visit laboratory to see real biomedical imaging devices in action.

Prerequisites: Signals and Systems or permission of the instructor, working knowledge of Matlab, and some image processing experience. Cross-listed courses: Prerequisites: and Biomedical Optical Imaging Fall: 9 units Biophotonics, or biomedical optics, is a field dealing with the application of optical science and imaging technology to biomedical problems, including clinical applications. The course introduces basic concepts in electromagnetism and light tissue interactions, including optical properties of tissue, absorption, fluorescence, and light scattering.

Imaging methods will be described, including fluorescence imaging, Raman spectroscopy, optical coherence tomography, diffuse optical spectroscopy, and photoacoustic tomography. The basic physics and engineering of each imaging technique are emphasized. Their relevance to human disease diagnostic and clinical applications will be included, such as breast cancer imaging and monitoring, 3D retinal imaging, ways of non-invasive tumor detection, as well as functional brain imaging in infants.

NOTE: is intended for undergraduates only. Prerequisite: Medical Devices Fall: 9 units This course is an introduction to the engineering, clinical, legal and regulatory aspects of medical device performance and failure. Topics covered include a broad survey of the thousands of successful medical devices in clinical use, as well as historical case studies of devices that were withdrawn from the market.

In-depth study of specific medical devices will include: cardiovascular medicine, orthopedics, and general medicine. We will study the principles of operation with hands-on examples , design evolution, and modes of failure. Additional lectures will provide basic information concerning biomaterials used for implantable medical devices metals, polymers, ceramics and their biocompatibility, mechanisms of failure wear, corrosion, fatigue, fretting, etc.

The level of technical content will require junior standing for MCS and CIT students, a degree in science or engineering for non-MCS or non-CIT graduate students, or permission of the instructor for all other students. This course surveys assistive technologies designed for a variety functional limitations - including mobility, communication, hearing, vision, and cognition - as they apply to activities associated with employment, independent living, education, and integration into the community.

This course considers not only technical issues in device development, but also the psychosocial factors and market forces that influence device acceptance by individuals and the marketplace. Open only to students with junior standing who have had at least one engineering class or by permission of instructor.

Prerequisite: Tissue Engineering Spring: 12 units This course will train students in advanced cellular and tissue engineering methods that apply physical, mechanical and chemical manipulation of materials in order to direct cell and tissue function. Students will integrate classroom lectures and lab skills by applying the scientific method to develop a unique project while working in a team environment, keeping a detailed lab notebook and meeting mandated milestones.

Emphasis will be placed on developing the written and oral communication skills required of the professional scientist. The class will culminate with a poster presentation session based on class projects. Pre-requisite: Knowledge in cell biology and biomaterials, or permission of instructor Molecular and Micro-scale Polymeric Biomaterials in Medicine Spring: 9 units This course will cover aspects of polymeric biomaterials in medicine from molecular principles to device scale design and fabrication.

Topics include the chemistry, characterization, and processing of synthetic polymeric materials; cell-biomaterials interactions including interfacial phenomena, tissue responses, and biodegradation mechanisms; aspects of polymeric micro-systems design and fabrication for applications in medical devices. Recent advances in these topics will also be discussed.

Applying engineering perspectives and approaches to study molecular mechanisms of cellular processes plays a critical role in the development of contemporary biology. At the same time, understanding the principles that govern biological systems provides critical insights into the development of engineering systems, especially in the micro- and nano-technology.

The goal of this course is to provide basic molecular cell biology for engineering students with little or no background in cell biology, with particular emphasis on the application of quantitative and system perspectives to basic cellular processes. Course topics include the fundamentals of molecular biology, the structural and functional organization of the cell, the cytoskeleton and cell motility, the mechanics of cell division, and cell-cell interactions.

Advanced undergraduate or graduate student standing is required. Prior completion of Modern Biology is suggested but not required. Prerequisites: or or Bioprocess Design Spring: 9 units This course is designed to link concepts of cell culture, bioseparations, formulation and delivery together for the commercial production and use of biologically-based pharmaceuticals; products considered include proteins, nucleic acids, and fermentation-derived fine chemicals.

Associated regulatory issues and biotech industry case studies are also included. The format of the course is a mixture of equal parts lecture, open discussion, and participant presentation. Course work consists of team-oriented problem sets of an open-ended nature and indivudual-oriented industry case studies. The goals of the course work are to build an integrated technical knowledge base of the manufacture of biologically based pharmaceuticals and U.

Working knowledge of cell culture and modern biology, biochemistry and differential equations is assumed. Pre-requisite: Cellular and Molecular Biotechnology or both Biochemistry and Chemical Reaction Engineering, or instructor permission. Prerequisites: or or Cellular and Molecular Biotechnology Fall: 9 units This course will provide students with an introduction to biotechnology in an engineering context.

The focus will be on using microorganisms to prepare therapeutically and technologically relevant biochemicals. Topics to be covered include cellular and microbial metabolism, recombinant DNA methodologies, bioreactor design, protein separation and purification, and systems approaches to biotechnology. Coupling of mass transfer and reaction processes will be a consistent theme as they are applied to rates of receptor-mediated solute uptake in cells, drug transport and biodistribution, and drug release from delivery vehicles.

Design concepts underlying advances in nanomedicine will be described. A goal of this course is provide a taxonomy of neuroengineering technologies for research or clinical application in the neurosciences. How can we understand the information being transmitted? This class will cover the basic engineering and statistical tools in common use for analyzing neural spike train data, with an emphasis on hands-on application.

Topics may include neural spike train statistics Poisson processes, interspike intervals, Fano factor analysis , estimation MLE, MAP , signal detection theory d-prime, ROC analysis, psychometric curve fitting , information theory, discrete classification, continuous decoding PVA, OLE , and white-noise analysis. Modern statistical and machine learning tools are needed to interpret the plethora of neural data being collected, both for 1 furthering our understanding of how the brain works, and 2 designing biomedical devices that interface with the brain.

This course will cover a range of statistical methods and their application to neural data analysis.

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At the same time, understanding the principles that govern biological systems provides critical insights into the development of engineering systems, especially in the micro- and nano-technology. The goal of this course is to provide basic molecular cell biology for engineering students with little or no background in cell biology, with particular emphasis on the application of quantitative and system perspectives to basic cellular processes.

Course topics include the fundamentals of molecular biology, the structural and functional organization of the cell, the cytoskeleton and cell motility, the mechanics of cell division, and cell-cell interactions. Advanced undergraduate or graduate student standing is required. Prior completion of Modern Biology is suggested but not required. Prerequisites: or or Bioprocess Design Spring: 9 units This course is designed to link concepts of cell culture, bioseparations, formulation and delivery together for the commercial production and use of biologically-based pharmaceuticals; products considered include proteins, nucleic acids, and fermentation-derived fine chemicals.

Associated regulatory issues and biotech industry case studies are also included. The format of the course is a mixture of equal parts lecture, open discussion, and participant presentation. Course work consists of team-oriented problem sets of an open-ended nature and indivudual-oriented industry case studies. The goals of the course work are to build an integrated technical knowledge base of the manufacture of biologically based pharmaceuticals and U. Working knowledge of cell culture and modern biology, biochemistry and differential equations is assumed.

Pre-requisite: Cellular and Molecular Biotechnology or both Biochemistry and Chemical Reaction Engineering, or instructor permission. Prerequisites: or or Cellular and Molecular Biotechnology Fall: 9 units This course will provide students with an introduction to biotechnology in an engineering context. The focus will be on using microorganisms to prepare therapeutically and technologically relevant biochemicals.

Topics to be covered include cellular and microbial metabolism, recombinant DNA methodologies, bioreactor design, protein separation and purification, and systems approaches to biotechnology. Coupling of mass transfer and reaction processes will be a consistent theme as they are applied to rates of receptor-mediated solute uptake in cells, drug transport and biodistribution, and drug release from delivery vehicles.

Design concepts underlying advances in nanomedicine will be described. A goal of this course is provide a taxonomy of neuroengineering technologies for research or clinical application in the neurosciences. How can we understand the information being transmitted? This class will cover the basic engineering and statistical tools in common use for analyzing neural spike train data, with an emphasis on hands-on application.

Topics may include neural spike train statistics Poisson processes, interspike intervals, Fano factor analysis , estimation MLE, MAP , signal detection theory d-prime, ROC analysis, psychometric curve fitting , information theory, discrete classification, continuous decoding PVA, OLE , and white-noise analysis.

Modern statistical and machine learning tools are needed to interpret the plethora of neural data being collected, both for 1 furthering our understanding of how the brain works, and 2 designing biomedical devices that interface with the brain. This course will cover a range of statistical methods and their application to neural data analysis. The statistical topics include latent variable models, dynamical systems, point processes, dimensionality reduction, Bayesian inference, and spectral analysis.

The neuroscience applications include neural decoding, firing rate estimation, neural system characterization, sensorimotor control, spike sorting, and field potential analysis. Prerequisites: ; , or equivalent introductory probability theory and random variables course; an introductory linear algebra course; senior or graduate standing. No prior knowledge of neuroscience is needed. This course integrates mechanical engineering, biomedical engineering, computer science, and mathematics together.

Topics to be studied include medical imaging, image processing, geometric modeling, visualization, computational mechanics, and biomedical applications. The techniques introduced are applied to examples of multi-scale biomodeling and simulations at the molecular, cellular, tissue, and organ level scales.

During this course students will examine the fluid dynamical phenomena underlying key components of "lab on a chip" devices. Students will have the opportunity to learn practical aspects of microfluidic device operation through hands-on laboratory experience, computer simulations of microscale flows, and reviews of recent literature in the field. Throughout the course, students will consider ways of optimizing device performance based on knowledge of the fundamental fluid mechanics.

Students will explore selected topics in more detail through a semester project. Pre-requisites: or or or instructor permission. Specific topics include: 1 the role of stresses in the cytoskeleton dynamics as related to cell growth, spreading, motility, and adhesion; 2 the generation of force and motion by moot molecules; 3 stretch-activated ion channels; 4 protein and DNA deformation; 5 mechanochemical coupling in signal transduction.

If time permits, we will also cover protein trafficking and secretion and the effects of mechanical forces on gene expression. Emphasis is placed on the biomechanics issues at the cellular and molecular levels; their clinical and engineering implications are elucidated. Prerequisite: Instructor permission. Prerequisites: None. Corequisites: None.

Cross Listed Courses: Notes: None. Reservations: Molecular Biomechanics Intermittent: 9 units This class is designed to present concepts of molecular biology, cellular biology and biophysics at the molecular level together with applications.

Emphasis will be placed both on the biology of the system and on the fundamental physics, chemistry and mechanics which describe the molecular level phenomena within context. In addition to studying the structure, mechanics and energetics of biological systems at the nano-scale, we will also study and conceptually design biomimetic molecules and structures. Fundamentals of DNA, globular and structured proteins, lipids and assemblies thereof will be covered. The main objective of the course is to understand mathematical modeling of solid materials such as bone and tissues, and fluid mechanics of blood and other biofluids such as synovial fluid, etc.

The course as a whole encourages class participation and discussion in a seminar-type fashion. The course begins with a historical review of the subject followed by a review of vector and tensor analysis, before discussing various measures of deformation and stress formulations. The development and understanding of appropriate constitutive models for particular problems are at the core of this course.

Both analytical and to some extent experimental results are presented through readings from reports in recent journals and the relevance of these results to the solution of unsolved problems is highlighted. The intent is to provide the basic ideas of continuum mechanics for engineering and science students with little or no background in biomechanics or mathematical modeling, with particular emphasis on the application of quantitative and system perspectives to fluid and solid mechanics problems.

In addition to looking at various examples with physiological applications, the last few weeks of the course are dedicated to discussing individually-crafted research projects for the students. After a brief review of cardiovascular physiology and fluid mechanics, the students will progress from modeling blood flow in a.

The students will also learn how to calculate mechanical forces on cardiovascular tissue blood vessels, the heart and cardiovascular cells endothelial cells, platelets, red and white blood cells , and the effects of those forces. Lastly, the students will learn various methods for modeling cardiac function. When applicable, students will apply these concepts to the design and function of selected medical devices heart valves, ventricular assist devices, artificial lungs.

Students will interact with clinical practitioners and investigate the technological challenges that face these practitioners. A number of visits to the medical center are anticipated for hands on experience with a number of technologies utilized by surgeons to demonstrate the result of advances in biomedical engineering. These experiences are expected to include microvascular surgery, robotic surgery, laparoscopic, and endoscopic techniques.

Tours of the operating room and shock trauma unit will be arranged. If possible observation of an operative procedure will be arranged if scheduling permits. Invited surgeons will represent disciplines including cardiovascular surgery, plastic and reconstructive surgery, surgical oncology, trauma surgery, minimally invasive surgery, oral and maxillofacial surgery, bariatric surgery, thoracic surgery, orthopedic surgery, and others.

This course meets once a week for 3 hours. Several sessions will be held at the Medical Center, transport provided. Pre-requisite: Physiology and one of the introductory engineering courses, , , Emphasis will be placed on enabling students to use currently available numerical methods rather than developing anew to solve engineering problems. Upon completing the course, the successful student will be able to use basic knowledge regarding computer architecture, data types, binary arithmetic, and programming, to solve sample quantitative problems in engineering.

Topics will include: solving linear systems of equations, model fitting using least squares techniques linear and nonlinear , data interpolation, numerical integration and differentiation, solving differential equations, and data visualization. Specific example computations in each topic above will be drawn from problems in physics, chemistry, as well as signal and image processing, and biomedical engineering.

Students will work independently in groups for a final project. May count as practicum for practicum-option MS. Pre-requisite: Calculus, multivariate calculus, linear algebra, and differential equations Bioinstrumentation Intermittent: 9 units This course aims to build the foundation of basic principles, applications and design of bioinstrumentation. Topics covered include biosignals recording, transducers for biomedical application, action potentials EMG, EEG, ECG, amplifiers and signal processing, blood flow and pressure measurements, data acquisition and signal conditioning, spectral analysis of data, filtering, and safety aspects of electrical measurements.

Ultimately, students will learn 1 how to apply basic circuit theory to perform measurement of biosignals, 2 be familiar and use common measurement devices, such as multimeter and oscilloscope, 3 be familiar with Op-amps circuits, 4 how to acquire and analyze a signal using time and frequency techniques, and 5 how to filter a signal to remove noise.

Students will gain experience in the analysis of host responses to these biomaterials as well as strategies to control host interaction. Biomaterial biocompatibility, immune interactions, tissue healing and regeneration will be addressed. Students will integrate classroom lectures with laboratory skills evaluating host-material interactions in a laboratory setting. Laboratory characterization techniques will include cell culture techniques, microscopic, cytochemical, immunocytochemical and histological analyses.

Prerequisite: junior or senior standing in Biomedical Engineering or consent of the instructor. The course will focus on common complex conditions and diseases such as inflammatory bowel disease IBD , pancreatitis, diabetes mellitus and obesity, rheumatoid arthritis, multiple sclerosis, pain syndrome and pharmacogenetics. Improvement in care of these conditions requires a reverse engineering approach, and new tools because of the complexity and unpredictability of clinical course and best treatments on a case-by-case basis.

The course includes introduction to medical genetics, biomarkers of disease, health records, disease modeling, outcome predictions, therapies, remote monitoring and smart applications. Special lectures on health economics and career opportunities are also planned. Each session will include didactic lectures, workshops and development of applications. Students will gain experience exploring genetic variants associated with common diseases, including the opportunity to explore their own DNA.

Instructors: David C. It is organized into three units. The first unit introduces fundamental principles of biological imaging modalities, such as fluorescence microscopy, super-resolution microscopy, and electron microscopy.

These modalities are used to visualize and record biological structures and processes at the molecular and cellular levels. The second unit introduces fundamental principles of imaging modalities, such as magnetic resonance imaging, x-ray computed tomography, and ultrasound. These modalities are used to visualize and record medical structures and processes at the tissue and organ levels.

Recent developments in convergence of biological and medical imaging are briefly discussed. The third section introduces fundamentals of computational techniques used for analyzing and understanding biological and medical images, such as deconvolution, registration, segmentation, tracking, and pattern recognition.

The introduction to these topics will draw on concepts and techniques from several related fields, including physics, statistics, signal processing, computer vision, and machine learning. As part of the course, students will complete several independent projects. Students will also have the opportunity to visit laboratories to see some of the actual biomedical imaging devices in action. Prerequisites: Signals and Systems or permission of the instructor.

Proficiency in basic programming is expected. It will introduce students to the different types of stem cells as well as environmental factors and signals that are implicated in regulating stem cell fate. The course will highlight techniques for engineering of stem cells and their micro-environment.

It will evaluate the use of stem cells for tissue engineering and therapies. Emphasis will be placed on discussions of current research areas and papers in this rapidly evolving field. Students will pick a class-related topic of interest, perform a thorough literature search, and present their findings as a written report as well as a paper review and a lecture. Lectures and discussions will be complemented by practical lab sessions, including: stem cell harvesting and culture, neural stem cell transfection, differentiation assays, and immunostaining, polymeric microcapsules as advanced culture systems, and stem cell integration in mouse brain tissue.

The class is designed for graduate students and upper undergraduates with a strong interest in stem cell biology, and the desire to actively contribute to discussions in the class. The lectures review the structure and function of different body systems. Typical modes of failure disease are then described and illustrated with examples using actual de-identified cases based on over 30 years of experiences in the intensive care unit ICU by Dr.

Field trips are made to a local critical care and emergency medicine simulation facility at the University of Pittsburgh. An optional opportunity to participate in ICU rounds is also available. Requirements: Junior standing and higher Bio-nanotechnology: Principles and Applications Fall: 9 units "Have you ever wondered what is nanoscience and nanotechnology and their impact on our lives?

The students will then survey a range of biological applications of nanomaterials through problem-oriented discussions, with the goal of developing design strategies based on basic understanding of nanoscience. Examples include, but are not limited to, biomedical applications such as nanosensors for DNA and protein detection, nanodevices for bioelectrical interfaces, nanomaterials as building blocks in tissue engineering and drug delivery, and nanomaterials in cancer therapy.

The students will then survey a range of applications of nanomaterials through problem-oriented discussions, with the goal of developing design strategies based on basic understanding of nanoscience. Examples include, but are not limited to, biomedical applications such as nanosensors for DNA and protein detection, nanodevices for bioelectrical interfaces, nanomaterials as building blocks in tissue engineering and drug delivery, and nano materials in cancer therapy.

Pre-requisite: Graduate standing. College level chemistry or physical chemistry, and thermodynamics. The fundamentals of computational medical image analysis will be explored, leading to current research in applying geometry and statistics to segmentation, registration, visualization, and image understanding. Student will develop practical experience through projects using the National Library of Medicine Insight Toolkit ITK , a popular open-source software library developed by a consortium of institutions including Carnegie Mellon University and the University of Pittsburgh.

In addition to image analysis, the course will include interaction with clinicians at UPMC. It is possible that a few class lectures may be videoed for public distribution. It involves a theory of inventive problem solving known as Triz that teaches the student how to invent on demand. The structure of the course will follow a flipped classroom model: with reading assignments and pre-recorded lectures assigned before class and homework performed in-class.

This will allow students to learn the material at their own pace, and to translate theory to practice in a group setting with mentorship of the course instructor and teaching assistant, and teamwork of classmates.

Throughout the semester, specific problems will be assigned to the entire class on topics emphasizing cost saving affordable health care act , medicine for under-resourced settings, and global health. A final project will be required of each student on a topic of choice with instructor approval.

Each project will have an associated client from industry or healthcare who will serve as outside reviewer. The composition of the class will emphasize biomedical engineering students, but will also invite a limited enrollment of students from the School of Design, Tepper, and Heinz.

Accordingly, there will be emphasis on multi-disciplinary teamwork, and networking. In summary, the goals of this course are to: develop formal skills in inventive problem solving, gain proficiency in teamwork and networking, and to actually solve real-world problems in medicine. For all other students, permission of the instructor. The core exposes students to basic facets of biomedical engineering to lay a foundation. The tracks allow students to build depth in a specific aspect of biomedical engineering.

The capstone design engages students in team work to develop real-world applications. While most tracks are designed to parallel a traditional engineering discipline, a General Biomedical Engineering track is available for students intending on pursuing graduate studies or medical school, and a self-designed track allows students to pursue specific areas not covered by the pre-defined tracks.

The additional major in Biomedical Engineering should be declared at the same time when declaring a traditional engineering major. The course requirements for the BME portion of the additional major are as follows:. Also known as for Health Professions Program students. The BMTE track addresses issues at the interface of materials science, biology and engineering. The topics include the interactions between materials and cells or tissues, the effects of such interactions on cells and tissues, the design of materials for biological applications, and the engineering of new tissues.

Students of this track may develp careers in biotechnology, tissue engineering, biopharmaceuticals, and medical devices that leverage materials properties. The BMEC track addresses the application of solid or fluid mechanics to biological and medical systems. It provides quantitative understanding of the mechanical behavior of molecules, cells, tissues, organs, and whole organisms. The field has seen a wide range of applications from the optimzation of tissue regeneration to the design of surgical and rehabilitation devices.

Both provide the necessary foundation in the underlying physical principles and their non-Biomedical Engineering applications. Education in biomechanics enables students to pursue careers in medical devices or rehabilitation engineering. In addition to the Biomedical Engineering core courses, students in the BMEC Track must take must take the following combination of courses:.

Some Special Topics, newly offered or intermittently offered courses may be acceptable as track electives. Students should consult with their advisors and petition the BME Undergraduate Affairs Committee for permission to include such courses as track electives. This track prepares students for careers in medical imaging or smart prosthetics. The CMBT track emphasizes fundamentals and applications of biochemistry, biophysics, and cell biology, and processes on the nanometer to micrometer size scale.

Students in this track acquire understanding of the molecular and cellular bases of life processes, and build skills in quantitative modeling of live cell-based biotechnologies and in technologies that exploit the unique properties of biomolecules in non-biological settings.

The CMBT track is ideally suited for the combined education of Biomedical Engineering and Chemical Engineering, which provides a strong core of chemistry and molecular processing principles. The GBME track provides broader education in biomedical engineering than other tracks. It is aimed at students who intend on pursuing medical or graduate school and desire a general coverage of biomedical engineering with maximal flexibility in course selection.

Students are strongly encouraged to consult the advisor s and tailor the electives according to their career plan. In addition to the Biomedical Engineering core requirements, students must fullfill the following requirements. The SBME track is aimed at helping highly motivated students who have a strong sense of career direction that falls beyond the scope of regular Biomedical Engineering tracks.

Students are allowed to design the "track" portion of the curriculum in consultation with the faculty. Example themes include medical robotics, neural engineering, or computational biomedical engineering. While the GBME track builds the breadth and may include only courses that are already associated with the four other defined tracks, the SBME track allows students to choose courses relevant to the theme from across the University. In addition to the Biomedical Engineering core requirements, students must take four elective courses of at least 9 units each.

These elective courses must form a coherent theme that is relevant to biomedical engineering. In addition, at least one of the elective courses must be judged by the Biomedical Engineering Undergraduate Affairs Committee to have substantial biological or medical content.

Students wishing to pursue a self-designed track should first consult with the Biomedical Engineering Undergraduate Affairs Committee. Contacts for the Committee are Prof. The proposal must include:. Once approved, the student must sign an agreement listing the theme and the four courses comprising the SBME track.

In the event that issues beyond the student's control, such as course scheduling or cancellation, prevent the student from completing the approved course plan, the student may petition the Biomedical Engineering Undergraduate Affairs Committee to. Conrad M.

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